简介

王路路，女，1991年，汉族，中共党员，讲师。2022年博士毕业于大连理工大学生物化工专业；2022.12-2024.09就职于无锡佰翱得生物科学有限公司担任项目经理，高级研究员；2024.09至今为大连民族大学生命科学学院生物工程系教师。在相关领域期刊发表SCI论文20余篇，发明专利2项，中文核心3篇，其他英文论文5篇。在教学上主要讲授《分子生物学及基因工程》本科生课程。

研究方向

（1）致病菌关键酶的结构解析、功能研究及酶的改造；

（2）致病菌中重要双组份信号转导系统的研究；

（3）基于新药研发的膜蛋白功能研究及先导化合物发掘。

代表性成果情况

(1)Lulu Wang, Tingting Bu, Xue Bai, et al. Crystal Structure of the Domain-Swapped Dimeric Maltodextrin-Binding Protein MalE from Salmonella enterica. Acta Crystallogr D Struct Biol, 2022, 78(5):613-622. (SCI一区，IF=7.652)

(2)Dan Xie, Lulu Wang (共一), Qi Xiao, et al. New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide. INT J MOL SCI, 2018, 19(5):1393. (SCI一区，IF=6.208)

(3)Shanru He, Yuanyuan Chen, Lulu Wang (共一), et al. Structural and Functional Analysis of the Pyridoxal Phosphate Homeostasis Protein YggS from Fusobacterium nucleatum. Molecules, 2022, 27: 4781. (SCI二区，IF=4.927)

(4)Lulu Wang, Ruochen Fan, Haodi Ma, et al. Genomic and metabolomic insights into the antimicrobial compounds and plant growth-promoting potential of Bacillus velezensis Q-426. BMC genomics, 2023, 24: 589. (SCI二区，IF=4.4)

(5)Lulu Wang, Ruochen Fan, Zhuting Li, et al. Insights into the structure and function of the histidine kinase ComP from Bacillus amyloliquefaciens based on the artificial intelligence approach. Bioscience Reports, 2022, 42(10). (SCI三区, IF=3.976)

(6)Lulu Wang, Yuanyuan Chen, Fei Shang, et al. Structural insight into the carboxylesterase BioH from Klebsiella pneumonia. Biochem Biophys Res Commun, 2019, 520: 538-543. (SCI三区, IF=3.322)

(7)Yuanyuan Chen, Lulu Wang (共一), Fei Shang, et al. Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae. Biochem Biophys Res Commun, 2019, 518(3): 513-518. (SCI三区, IF=3.322)

(8)Jinli Chen, Lulu Wang (共一), Fei Shang, et al. Crystal structure of E. coli ZinT with one zinc-binding mode and complexed with citrate. Biochem Biophys Res Commun, 2018, 500(2): 139-144. (SCI三区, IF= 3.322)

(9)Yongbin Xu, Lulu Wang (共一), Jinli Chen, et al. Structural and Functional Analyses of Periplasmic5’-Methylthioadenosine/S‑Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila. Biochemistry, 2017, 56(40): 5347-5355. (SCI三区, IF=3.321)

(10)Lulu Wang, Yuanyuan Chen, Wei Liu, Jing Lan, Fei Shang, Chunshan Quan, Yongbin Xu. Cytosolic 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase MtaN from Mycobacterium smegmatis: purification, crystallization and X-ray crystallographic analysis. Biodesign, 2019, 7(3): 61-66.

邮箱

60240017@dlnu.edu.cn

wanglulu0813@126.com